Overview

The server exposes 13 tools. Each one is documented below with its purpose, arguments, return shape, and the upstream EMBL-EBI service it draws on. Every tool returns a JSON string.

Most tools that take an entry accession accept either an InterPro accession (IPRxxxxxx) or a member-database signature (Pfam PF00069, PANTHER PTHR11961, CATH-Gene3D G3DSA:1.10.760.10, SMART SM00220, CDD cd00108, …). The source database is resolved automatically from the accession — first from the accession prefix, then, when that is ambiguous (notably PROSITE patterns vs profiles), from an EBI Search id lookup — so you never pass a database yourself. (browseEntries is the exception: there database selects which collection to list.)

Tools at a glance

Tool	Backend	What it does
searchInterPro	EBI Search	Free-text / keyword discovery when you don’t know an accession.
getEntry	InterPro API	Full metadata for one entry or member-DB signature.
browseEntries	InterPro API	Paginated browse/filter of entries by database, type and/or GO term.
searchByGoTerm	InterPro API	GO term → the InterPro entries annotated with it.
getProteinEntries	InterPro + Matches API	All domain annotations of a UniProt protein, with locations.
getDomainArchitectures	InterPro API	The recurring domain architectures (IDAs) an entry occurs in.
searchDomainArchitectures	InterPro API	The domain architectures matching a set of domains (organisation search).
getTaxonomicDistribution	InterPro API	Protein counts across the NCBI taxonomy tree for an entry.
getEntryProteins	InterPro API	List UniProt proteins matched by an entry (reviewed / taxon filters).
getEntryStructures	InterPro API	List PDB structures that contain an entry.
matchSequences	Matches API	Precomputed matches for one or more sequences/MD5s (up to 100).
analyzeSequence	InterProScan 6	Runs InterProScan on a (possibly novel) sequence.
getSequenceAnalysis	InterProScan 6	Retrieve a previously submitted analysis job by id.